The transcription factors aryl hydrocarbon receptor and MYC cooperate in the regulation of cellular metabolism
M. Carmen Lafita‐Navarro, Lizbeth Perez‐Castro, Lauren G. Zacharias, Spencer Barnes, Ralph J. DeBerardinis, Maralice Conacci‐Sorrell
Abstract
but did not affect UMP levels, likely because of compensatory mechanisms in these cells. Our results indicate that AHR contributes to the regulation of metabolic pathways necessary for the proliferation of transformed cells.
Topics & Concepts
Aryl hydrocarbon receptorTranscription factorTranscription (linguistics)MetabolismChemistryArylCell biologyCancer researchBiologyBiochemistryGeneOrganic chemistryPhilosophyAlkylLinguisticsCancer, Hypoxia, and MetabolismAdipose Tissue and MetabolismEpigenetics and DNA Methylation