The Struggle Continues: Improving Outcomes for Surrogate Decision-Makers after the ICU
Katherine R. Courtright, James Downar
Abstract
understanding of sepsis but also underscores the importance of addressing its heterogeneity on a global scale.The evolution of sepsis research highlights the harmonization of cohort designs, data collection, sample processing, and biological analysis.In addition to multiomic data integration and context-specific treatment effect analysis, future RCTs that use precision-guided enrollment are needed to confirm that these strategies improve outcomes.The important contribution of the present study (7) highlights the critical role of global collaboration in advancing individualized sepsis management by 2035.
Topics & Concepts
MedicineIntensive care unitIntensive care medicineSurrogate endpointIntensive careMEDLINEInternal medicineLawPolitical sciencePalliative Care and End-of-Life IssuesEthics in medical practicePatient Safety and Medication Errors