Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia
Bernd B. Zeisig, Tsz Kan Fung, Magdalena Zarowiecki, Chiou Tsun Tsai, Huacheng Luo, Boban Stanojević, Claire Lynn, Anskar Y.H. Leung, Jan Zuna, Markéta Žaliová, Martin Bornhäuser, Malte von Bonin, Boris Lenhard, Suming Huang, Ghulam J. Mufti, Chi Wai Eric So
Abstract
infection, effectively resensitized HSC-derived MLL-AML toward standard chemotherapeutic drugs. This study not only functionally established two distinctive origins of human LSCs for MLL-AML and their role in mediating chemoresistance but also identified a potential therapeutic avenue for stem cell-associated treatment resistance by repurposing a well-tolerated antidiarrhea drug already used in the clinic.
Topics & Concepts
Stem cellLeukemiaCancer researchMyeloid leukemiaBiologyVulnerability (computing)MedicineOncologyImmunologyGeneticsComputer securityComputer scienceAcute Myeloid Leukemia ResearchChronic Lymphocytic Leukemia ResearchCAR-T cell therapy research