Synthesis of spiroindolenine-3,3′-pyrrolo[2,1-<i>b</i>]quinazolinones through gold(<scp>i</scp>)-catalyzed dearomative cyclization of <i>N</i>-alkynyl quinazolinone-tethered indoles
Wang Wang, Pei‐Sen Zou, Li Pang, Yao Lei, Ziyi Huang, Nan‐Ying Chen, Dong‐Liang Mo, Cheng‐Xue Pan, Gui‐Fa Su
Abstract
An efficient gold( i )-catalyzed dearomative cyclization of N -alkynyl quinazolinone-tethered C2-substituted indoles to prepare various spiroindolenine-3,3′-pyrrolo[2,1- b ]quinazolinones in good to excellent yields is reported.
Topics & Concepts
QuinazolinoneChemistrySubstrate (aquarium)Combinatorial chemistryCatalysisFunctional groupStereochemistryMedicinal chemistryOrganic chemistryGeologyPolymerOceanographyQuinazolinone synthesis and applicationsCatalytic C–H Functionalization MethodsMulticomponent Synthesis of Heterocycles