Low-Dose Colchicine in Patients With Type 2 Diabetes and Recent Myocardial Infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT)
François Roubille, Nadia Bouabdallaoui, Simon Kouz, David D. Waters, Rafael Díaz, Aldo P. Maggioni, Fausto J. Pinto, Jean‐Claude Grégoire, Habib Gamra, Ghassan S. Kiwan, Colin Berry, José López‐Sendón, Wolfgang Köenig, Laurent Delorme, Meyer Elbaz, Pierre Coste, Mylène Provencher, Zohar Bassevitch, Lucie Blondeau, Philippe L. L’Allier, Marie‐Claude Guertin, Jean‐Claude Tardif
Abstract
OBJECTIVE: The cardiovascular benefits of low-dose colchicine have been demonstrated in patients with coronary disease. Its effects were evaluated in this prespecified analysis in patients with type 2 diabetes (T2D) from the Colchicine Cardiovascular Outcomes Trial (COLCOT). RESEARCH DESIGN AND METHODS: COLCOT was a randomized, double-blinded trial of colchicine, 0.5 mg daily, versus placebo initiated within 30 days after a myocardial infarction. RESULTS: There were 959 patients with T2D enrolled and monitored for a median of 22.6 months. A primary end point event occurred in 8.7% of patients in the colchicine group and in 13.1% in the placebo group (hazard ratio 0.65; 95% CI 0.44-0.96; P = 0.03). Nausea was reported in 2.7% and 0.8% in the study groups (P = 0.03), and pneumonia occurred in 2.4% and 0.4% (P = 0.008). CONCLUSIONS: Among patients with T2D and a recent myocardial infarction, colchicine, 0.5 mg daily, leads to a large reduction of cardiovascular events. These results support the conduct of the COLCOT-T2D trial in primary prevention.