Chronic kidney disease ten years after pediatric allogeneic hematopoietic stem cell transplantation
Gertjan Lugthart, Carlijn Jordans, Anne P.J. de Pagter, Dorine Bresters, Cornelia M. Jol‐van der Zijde, Joëll E. Bense, Roos W. G. van Rooij-Kouwenhoven, Rám N. Sukhai, Marloes Louwerens, Eiske M. Dorresteijn, Arjan C. Lankester
Abstract
but recovery within 28 days were not associated with CKD. Furthermore, hematological malignancy as HSCT indication was an independent risk factor for CKD. One third of patients had both CKD criteria, one third had isolated eGFR reduction and one third only had albuminuria. Hypertension occurred in 27% of patients with CKD compared to 4.4% of patients without. Tubular proteinuria was present in 7% of a subgroup of 71 patients with available β2-microglobulinuria. Thus, a significant proportion of pediatric HSCT recipients developed CKD within ten years. Our data stress the importance of structural long-term monitoring of eGFR, urine and blood pressure after HSCT to identify patients with incipient CKD who can benefit from nephroprotective interventions.