Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques
Suhas Sureshchandra, Chi Ngai Chan, Jacob J. Robino, Lindsay K. Parmelee, Michael J. Nash, Stephanie R. Wesolowski, Eric M. Pietras, Jacob E. Friedman, Diana Takahashi, Weining Shen, Xiwen Jiang, Jon D. Hennebold, Devorah C. Goldman, William Packwood, Jonathan R. Lindner, Charles T. Roberts, Benjamin J. Burwitz, Ilhem Messaoudi, Oleg Varlamov
Abstract
mice. Collectively, these data demonstrate for the first time that maternal WSD impairs fetal HSPC differentiation and function in a translationally relevant nonhuman primate model.
Topics & Concepts
BiologyProgenitor cellHaematopoiesisFetusStem cellImmunologyBone marrowIn uteroCell biologyPregnancyGeneticsSingle-cell and spatial transcriptomicsBirth, Development, and HealthNeonatal Respiratory Health Research