Roles of the adaptor protein tumor necrosis factor receptor type 1-associated death domain protein (TRADD) in human diseases
Yun Chen, Yunhui Gu, Xing Xiong, Yangyang Zheng, Xiao Liu, Weiqi Wang, Guoliang Meng
Abstract
)，TRADD can bind to the receptors, serving as a platform for the recruitment of the downstream molecules for signal propagating and thus mediating various physiological and pathological processes. In this review, we provide a brief overview of the current knowledge on TRADD and discuss the roles of TRADD in infectious and inflammatory diseases, cardiovascular diseases, central nervous system diseases, cancer, endometriosis, hepatocyte proliferation, preterm birth and perinatal development.
Topics & Concepts
TRADDDeath domainSignal transducing adaptor proteinTumor necrosis factor receptorTumor necrosis factor alphaVascular endothelial growth inhibitorCancer researchReceptorMedicineBiologyImmunologyApoptosisInternal medicineProgrammed cell deathGeneticsVEGF receptorsVascular endothelial growth factorVascular endothelial growth factor AImmune Response and Inflammationinterferon and immune responsesCytokine Signaling Pathways and Interactions