SYPRO Orange – a new gold standard amyloid probe
Aruna K. Mora, Sukhendu Nath
Abstract
SYPRO Orange, a zwitterionic merocyanine dye, can strongly interact with amyloid fibrils and shows enormous (∼1200 times) increase in its emission intensity. The sensitivity of the new probe is several times higher than that of the gold standard amyloid probe thioflavin T. Unlike thioflavin-T, the new probe has spectral properties suitable for in vivo imaging with detection sensitivity in the picomolar range.
Topics & Concepts
Gold standard (test)ThioflavinOrange (colour)Amyloid (mycology)ChemistryMedicinePathologyAlzheimer's diseaseInternal medicineInorganic chemistryDiseaseFood scienceAlzheimer's disease research and treatmentsMolecular Sensors and Ion DetectionComputational Drug Discovery Methods