Development of N,P-doped carbon quantum dots as a green fluorescent probe for fexofenadine determination: mechanistic studies, Box–Behnken optimization, and pharmacokinetic application
Ali Alqahtani, Taha Alqahtani, Adel Al Fatease, Adil Alshehri, Ahmed A. Almrasy
Abstract
, which aligned well with previously reported pharmacokinetic behavior. The greenness and practicality of the proposed method were evaluated using the AGREE, MOGAPI and BAGI tools, indicating its superior environmental sustainability and acceptable practical applicability compared to conventional HPLC-UV and UPLC-MS/MS techniques and presenting its suitability for routine pharmaceutical and bioanalytical applications.
Topics & Concepts
Box–Behnken designFexofenadineFluorescenceQuantum dotCarbon quantum dotsNanotechnologyChemistryMaterials scienceChromatographyPharmacologyResponse surface methodologyMedicinePhysicsQuantum mechanicsCarbon and Quantum Dots ApplicationsElectrochemical sensors and biosensorsAnalytical chemistry methods development