Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition
Mahesh Tambe, Ella Karjalainen, Markus Vähä‐Koskela, Daria Bulanova, Bjørn Tore Gjertsen, Mika Kontro, Kimmo Porkka, Caroline A. Heckman, Krister Wennerberg
Topics & Concepts
MCL1Myeloid leukemiaCancer researchMAPK/ERK pathwayApoptosisMyeloidLeukemiaProgrammed cell deathMEK inhibitorAzacitidineMedicineBiologySignal transductionImmunologyDownregulation and upregulationCell biologyBiochemistryGene expressionDNA methylationGeneCell death mechanisms and regulationProtein Degradation and InhibitorsMelanoma and MAPK Pathways