SRSF1 serves as a critical posttranscriptional regulator at the late stage of thymocyte development
Zhihong Qi, Fang Wang, Guotao Yu, Di Wang, Yingpeng Yao, Menghao You, Jingjing Liu, Juanjuan Liu, Zhen Sun, Ce Ji, Yuanchao Xue, Shuyang Yu
Abstract
expression via alternative splicing in response to type I interferon signaling. Moreover, forced expression of interferon regulatory factor 7 rectifies the defects in SRSF1-deficient thymocyte maturation via restoring expression of type I interferon-related genes. Thus, our work provides new insight on SRSF1-mediated posttranscriptional regulatory mechanism of thymocyte development.
Topics & Concepts
ThymocyteBiologyCell biologyInterferonInterferon regulatory factorsRegulatorT-cell receptorT cellCancer researchTranscription factorImmunologyGeneImmune systemGeneticsImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses