Impact of pre-existing anti-polyethylene glycol (PEG) IgM on biodistribution and humoral response of intramuscularly administered PEGylated mRNA loaded lipid nanoparticle
Shunji Abe, Haruka Takata, Taro Shimizu, Yoshino Kawaguchi, Shoichiro Fukuda, Haruka Yamamoto, Hidenori Ando, Tatsuhiro Ishida
Topics & Concepts
PEGylationImmunogenicityBiodistributionAntibodyIn vivoPEG ratioChemistryMessenger RNAPolyethylene glycolPharmacologyMedicineImmunologyIn vitroBiochemistryBiologyFinanceEconomicsGeneBiotechnologyRNA Interference and Gene DeliverySARS-CoV-2 and COVID-19 ResearchImmune Cell Function and Interaction