An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice
Liliane Khoryati, Minh N. Pham, McKenna Sherve, Swarnima Kumari, Kevin D. Cook, Josh T. Pearson, Marika Bogdani, Daniel Campbell, Marc A. Gavin
Abstract
cell selectivity in an IL-2R proximal response. These properties facilitated potent and extended resolution of NOD diabetes with infrequent dosing schedules.
Topics & Concepts
AutoimmunityNOD miceNodIL-2 receptorImmunologyRegulatory T cellBiologyCell biologyDiabetes mellitusImmune systemT cellEndocrinologyImmune Cell Function and InteractionT-cell and B-cell ImmunologyDiabetes and associated disorders