Genomic and expressional dynamics of ovarian cancer cell lines in PARPi treatment revealed mechanisms of acquired resistance
Aoshuang Cheng, Qunxian Rao, Yunyun Liu, Chunxian Huang, Jing Li, Chuying Huo, Zhongqiu Lin, Huaiwu Lu
Topics & Concepts
OlaparibBiologyCancer researchExome sequencingSynthetic lethalityCancerPhenotypeGeneticsGenePoly ADP ribose polymeraseDNA repairPolymerasePARP inhibition in cancer therapyOvarian cancer diagnosis and treatmentDNA Repair Mechanisms