The Allylic Alkylation of Ketone Enolates
Lukas Junk, Uli Kazmaier
Abstract
The palladium-catalyzed allylic alkylation of non-stabilized ketone enolates was thought for a long time to be not as efficient as the analogous reactions of stabilized enolates, e. g. of malonates and β-ketoesters. The field has experienced a rapid development during the last two decades, with a range of new, highly efficient protocols evolved. In this review, the early developments as well as current methods and applications of palladium-catalyzed ketone enolate allylations will be discussed.
Topics & Concepts
KetoneTsuji–Trost reactionAlkylationPalladiumAllylic rearrangementChemistryCatalysisOrganic chemistryCombinatorial chemistryAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry MethodsCatalytic C–H Functionalization Methods