WHO global research priorities for antimicrobial resistance in human health
Silvia Bertagnolio, Zlatina Dobreva, Chad M. Centner, Ioana D. Olaru, Daniele Donà, Stefano Burzo, Benedikt Huttner, Antoine Chaillon, Nebiat Gebreselassie, Teodora Wi, Mateusz Hasso-Agopsowicz, Benedetta Allegranzi, Hatim Sati, Verica Ivanovska, Kavita Kothari, Hanan H. Balkhy, Alessandro Cassini, Raph L Hamers, Kitty Van Weezenbeek, David Aanensen, Alexandre Alanio, Ana Alastruey-Izquierdo, Tinsae Alemayehu, Majdi Al-Hasan, Karel Allegaert, Amal Saif Al-Maani, Jameela Al-Salman, Abeer Nizar Alshukairi, Afreenish Amir, Tanya Applegate, George F Araj, Marlen Arce Villalobos, Christine Årdal, Diane Ashiru-Oredope, Elizabeth A Ashley, François-Xavier Babin, Laura H Bachmann, Till Bachmann, Kate Susan Baker, Manica Balasegaram, Colleen Bamford, Fernando Baquero, Laura Isabel Barcelona, Quique Bassat, Matteo Bassetti, Sulagna Basu, Justin Beardsley, Grey Benoit Vásquez, James A Berkley, Anuj K Bhatnagar, Julia Bielicki, Julie Bines, Felix Bongomin, Robert A Bonomo, John S Bradley, Catriona Bradshaw, Ana Brett, Adrian Brink, Colin Brown, Jeremy Brown, Kirsty Buising, Carolee Carson, Anna Cristina Carvalho, Elio Castagnola, Marco Cavaleri, Michele Cecchini, Chishala Chabala, Richard E Chaisson, Arunaloke Chakrabarti, Clare Chandler, Sujith John Chandy, Esmita Charani, Lisa Chen, Francesca Chiara, Anuradha Chowdhary, Arlene Chua, Pem Chuki, Doo Ryeon Chun, Gavin Churchyard, Daniela Cirillo, Lauren Clack, Susan E Coffin, Jennifer Cohn, Michelle Cole, John Conly, Ben Cooper, Alejandra Corso, Sara E Cosgrove, Helen Cox, Charles L Daley, Saffiatou Darboe, Tom Darton, Gerry Davies, Viviana de Egea, Amela Dedeić-Ljubović, Miranda Deeves, Claudia Denkinger, Jo-Anne R Dillon, Angela Dramowski, Brian Eley
Abstract
The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.