Direct C–H Functionalization of Phenanthrolines: Metal- and Light-Free Dicarbamoylations
David T. Mooney, Benjamin D. T. Donkin, Nemrud Demirel, Peter R. Moore, Ai‐Lan Lee
Abstract
A direct method for C-H dicarbamoylations of phenanthrolines has been developed, which is capable of directly installing primary, secondary as well as tertiary amides. This is a significant improvement on the previous direct method, which was limited to primary amides. The metal-, light-, and catalyst-free Minisci-type reaction is cheap, operationally simple, and scalable. We demonstrate that the step efficiency toward dicarbamoylated phenanthroline targets can now be significantly improved.
Topics & Concepts
Surface modificationCombinatorial chemistryPhenanthrolinePrimary (astronomy)CatalysisMetalChemistryNanotechnologyMaterials scienceInorganic chemistryOrganic chemistryPhysicsPhysical chemistryAstronomyCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis