The spectrum of beta-thalassemia mutations in the 22 Arab countries: a systematic review
Aisha Moeen Khan, Asma Al-Sulaiti, Salma Younes, Mohamed A. Yassin, Hatem Zayed
Abstract
OBJECTIVES: gene in Arab patients with β-thal. METHODS: Authors searched five databases (PubMed, Science Direct, Scopus, Web of Science, and Google Scholar) from the time of inception until March 2020. RESULTS: gene mutations among Arabs were c.93-21 G > A, c.118 C > T, c.92 + 1 G > A, c.92 + 6 T > C, c.92 + 5 G > C, c.315 + 1 G > A, and c.27dupG. Consanguinity is high among Arab patients with β-thal. Migration into Arab countries led to allelic heterogeneity among Arab patients with β-thal. CONCLUSION: Our findings present a platform for further genetic epidemiological studies for Arab patients with β-thal.
Topics & Concepts
ExonMedicineIntronGeneticsGeneAlleleThalassemiaConsanguinityTraditional medicineInternal medicineBiologyPediatricsHemoglobinopathies and Related DisordersBlood groups and transfusionNeonatal Health and Biochemistry