Microbiological Characterization of VNRX-5236, a Broad-Spectrum β-Lactamase Inhibitor for Rescue of the Orally Bioavailable Cephalosporin Ceftibuten as a Carbapenem-Sparing Agent against Strains of <i>Enterobacterales</i> Expressing Extended-Spectrum β-Lactamases and Serine Carbapenemases
Cassandra L. Chatwin, Jodie C. Hamrick, Robert E. Lee Trout, Cullen L. Myers, Susan M. Cusick, Jason Weiss, Mark Pulse, L Xerri, Christopher J. Burns, Greg Moeck, Denis M. Daigle, Kaitlyn John, Tsuyoshi Uehara, Daniel C. Pevear
Abstract
There is an urgent need for oral agents to combat resistant Gram-negative pathogens. Here, we describe the characterization of VNRX-5236, a broad-spectrum boronic acid β-lactamase inhibitor (BLI), and its orally bioavailable etzadroxil prodrug, VNRX-7145.
Topics & Concepts
CephalosporinChemistryKlebsiella pneumoniaeCarbapenemMeropenemEscherichia coliPharmacologyMicrobiologyMedicineAntibioticsAntibiotic resistanceBiochemistryBiologyGeneAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyPneumocystis jirovecii pneumonia detection and treatment