A metal–phenolic network-based multifunctional nanocomposite with pH-responsive ROS generation and drug release for synergistic chemodynamic/photothermal/chemo-therapy
Xiangyu Meng, Lizhu Chen, Rongmu Lv, Mei Liu, Nongyue He, Zhifei Wang
Abstract
) into a highly toxic hydroxyl radical (˙OH) via the Fenton reaction. The exposed DOX can enter the cell nucleus to induce chemotherapy. The released ICG can locate the distribution of nanocomposites in the body. Besides, the heat generated from PID@Fe-TA after NIR laser irradiation can further promote the therapeutic effect of PPT-enhanced CDT. Importantly, an excellent therapeutic efficacy is achieved both in in vitro and in vivo via the CDT/PTT/chemotherapy combination based on this "all-in-one" nanoplatform, providing a good paradigm for effective cancer eradication.
Topics & Concepts
Photothermal therapyNanocompositeDrugMetalMaterials scienceNanotechnologyBiophysicsChemistryPharmacologyMedicineBiologyMetallurgyNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisLuminescence and Fluorescent Materials