Design, synthesis, and antiproliferative activity of new 1,2,3-triazole/quinazoline-4-one hybrids as dual EGFR/BRAF<sup>V600E</sup> inhibitors
Amira M. Mohamed, Ola M. F. Abou‐Ghadir, Yaser A. Mostafa, Zainab M. Almarhoon, Stefan Braese, Bahaa G. M. Youssif
Abstract
A series of new quinazoline/1,2,3-triazole hybrids were designed and synthesized. The new compounds were evaluated as antiproliferative agents targeting EGFR, and BRAF V600E .
Topics & Concepts
QuinazolineTriazoleHybridChemistryOxadiazoleCancer researchCombinatorial chemistryBiologyOrganic chemistryBotanyQuinazolinone synthesis and applicationsMelanoma and MAPK PathwaysSynthesis and biological activity