Kinetic Studies of the Effect of pH on the Trypsin-Catalyzed Hydrolysis of <i>N</i>-α-benzyloxycarbonyl-<scp>l</scp>-lysine-<i>p</i>-nitroanilide: Mechanism of Trypsin Catalysis
J. Paul G. Malthouse
Abstract
). A catalytic mechanism is proposed to explain the pH dependence of catalysis.
Topics & Concepts
ChemistryTetrahedral carbonyl addition compoundEnzyme kineticsOxyanionAcylationProtonationCatalysisHydrolysisTrypsinHistidineCarboxylateMedicinal chemistryStereochemistryActive siteEnzymeOrganic chemistryIonNucleophileProtein Interaction Studies and Fluorescence AnalysisHemoglobin structure and functionLipid Membrane Structure and Behavior