A palladium-catalyst stabilized in the chiral environment of a monoclonal antibody in water
Yuichiro Kobayashi, Keisuke Murata, Akira Harada, Hiroyasu Yamaguchi
Abstract
We report the first preparation of a monoclonal antibody (mAb) that can immobilize a palladium (Pd)-complex. The allylic amination reaction using a supramolecular catalyst consisting of the Pd-complex and mAb selectively gives the (R)-enantiomer product with an enantiomeric excess (ee) of 98 ± 2%. This is in sharp contrast to the reaction catalyzed by a conventional Pd-catalyst (ee < 2%).
Topics & Concepts
CatalysisPalladiumMonoclonal antibodyChemistryCombinatorial chemistryAntibodyOrganic chemistryBiologyImmunologyChemical Synthesis and AnalysisSupramolecular Chemistry and ComplexesInnovative Microfluidic and Catalytic Techniques Innovation