Discovery of imidazopyrrolopyridines derivatives as novel and selective inhibitors of JAK2
Pengfei Xu, Pei Shen, Hai Wang, Lian Qin, Jie Ren, Qiushuang Sun, Raoling Ge, Jinlei Bian, Yi Zhong, Zhiyu Li, JuBo Wang, Zhixia Qiu
Topics & Concepts
ChemistryJanus kinase 2BioavailabilityPharmacologySelectivityTyrosine kinase 2CytokineGene isoformJanus kinaseIC50Cell growthChemical synthesisKinaseReceptorBiochemistryIn vitroInternal medicineGeneGrowth factorPlatelet-derived growth factor receptorMedicineCatalysisCytokine Signaling Pathways and InteractionsMyeloproliferative Neoplasms: Diagnosis and TreatmentAcute Myeloid Leukemia Research