Litcius/Paper detail

Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration

Taylor J. Fiolek, Christina L. Magyar, Tyler J. Wall, Steven B. Davies, Molly V. Campbell, Christopher J. Savich, Jetze J. Tepe, R. Adam Mosey

2021Bioorganic & Medicinal Chemistry Letters32 citationsDOIOpen Access PDF

Topics & Concepts

Intrinsically disordered proteinsProteasomeNeurodegenerationChemistrySmall moleculeDrug discoverySynucleinComputational biologyProteaseBiochemistryCell biologyDiseaseAlpha-synucleinParkinson's diseaseBiologyEnzymeMedicinePathologyUbiquitin and proteasome pathwaysProtein Degradation and InhibitorsGenetics and Neurodevelopmental Disorders