Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration
Taylor J. Fiolek, Christina L. Magyar, Tyler J. Wall, Steven B. Davies, Molly V. Campbell, Christopher J. Savich, Jetze J. Tepe, R. Adam Mosey
Topics & Concepts
Intrinsically disordered proteinsProteasomeNeurodegenerationChemistrySmall moleculeDrug discoverySynucleinComputational biologyProteaseBiochemistryCell biologyDiseaseAlpha-synucleinParkinson's diseaseBiologyEnzymeMedicinePathologyUbiquitin and proteasome pathwaysProtein Degradation and InhibitorsGenetics and Neurodevelopmental Disorders