Aziridine used as a vinylidene unit in palladium-catalyzed [2 + 2 + 1] domino annulation
Wen-Qing Zhu, Ziwei Zhang, Wen‐Yong Han, Yu-Chen Fang, Ping Yang, Lin-Qiang Li, Yong‐Zheng Chen
Abstract
A series of chromone fused methylenecyclopentanes are efficiently constructed in moderate to good yields by Pd-catalyzed [2 + 2 + 1] annulation, in which aziridine is used as a vinylidene unit by cleavage of two C–N bonds for the first time.
Topics & Concepts
AziridineAnnulationChemistryPalladiumDominoCatalysisChromoneCleavage (geology)Unit (ring theory)Medicinal chemistryOrganic chemistryCombinatorial chemistryPolymer chemistryRing (chemistry)EngineeringMathematicsGeotechnical engineeringFracture (geology)Mathematics educationCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Synthesis and Catalysis