CD206 modulates the role of M2 macrophages in the origin of metastatic tumors
Hui Li, Ying-Qi Miao, Liping Suo, Xi Wang, Yiqing Mao, Xuehui Zhang, Na Zhou, Jun-Rui Tian, Xiuyan Yu, Tong-Xia Wang, Yan Gao, Hongyan Guo, Zheng Zhang, Dian-Sheng Ma, Hongxia Wu, Yanwei Cui, Xiliang Zhang, Xiaochun Chi, Yu‐Chi Li, David M. Irwin, Gang Niu, Huanran Tan
Abstract
mouse models. In summary, we show that M2 macrophages in the blood circulation underwent a "change of loyalty" to become "cancer cells" that transformed into distal tissue metastasis, which could be suppressed by the knockdown of CD206 expression.
Topics & Concepts
MetastasisCancer researchIn vivoCancer cellGene knockdownOvarian cancerMedicineCancerMacrophagePhagocytosisMacrophage polarizationCell cultureBiologyPathologyIn vitroImmunologyInternal medicineBiochemistryGeneticsBiotechnologyPhagocytosis and Immune RegulationImmune cells in cancerExtracellular vesicles in disease