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Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity

Rosa Barreira da Silva, Ricardo Leitão, Ximo Pechuan-Jorge, Scott Werneke, Jason Oeh, Vincent Javinal, Yingyun Wang, Wilson Phung, Christine Everett, Jim Nonomiya, David Arnott, Cheng Lu, Yi-Chun Hsiao, James T. Koerber, Isidro Hötzel, James Ziai, Zora Modrušan, Thomas H. Pillow, Merone Roose‐Girma, Jill Schartner, Mark Merchant, Sascha Rutz, Céline Eidenschenk, Ira Mellman, Matthew L. Albert

2022Nature Immunology40 citationsDOI

Topics & Concepts

MonocyteCCL7ChemokineCancer researchMyeloidBiologyTumor microenvironmentInfiltration (HVAC)ImmunotherapyCell biologyCCL2Immune systemImmunologyThermodynamicsPhysicsImmune cells in cancerImmune Cell Function and InteractionCancer Immunotherapy and Biomarkers
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity | Litcius