Ellagic acid inhibits cell proliferation, migration, and invasion in melanoma via EGFR pathway.
Fan Wang, Jiangyan Chen, Debing Xiang, Xiaojuan Lian, Chunrong Wu, Quan Jin
Abstract
tumorigenesis of A375 cells. Moreover, elevated pEGFR expression was an independent detrimental factor for melanoma patients. Taken together, our study provided evidence that EA treatment inhibits the migration, invasion and proliferation of melanoma cells via EGFR signaling pathway. These findings strongly suggested that EA might be useful for the development of new therapeutic strategies at melanoma.
Topics & Concepts
MelanomaEllagic acidIn vivoCancer researchApoptosisCell growthCarcinogenesisIn vitroVimentinCell migrationCellChemistryCancerBiologyMedicinePolyphenolImmunohistochemistryImmunologyAntioxidantInternal medicineBiochemistryBiotechnologyPomegranate: compositions and health benefitsBioactive Compounds in PlantsTannin, Tannase and Anticancer Activities