Boosting two-photon photodynamic therapy with mitochondria-targeting ruthenium–glucose conjugates
Jiangping Liu, Xinxing Liao, Kai Xiong, Shi Kuang, Chengzhi Jin, Liang‐Nian Ji, Hui Chao
Abstract
Herein, we present a series of dual-targeted ruthenium-glucose conjugates that can function as two-photon absorption (TPA) PDT agents to effectively destroy tumors by preferentially targeting both tumor cells and mitochondria. The in vivo experiments revealed an excellent tumor inhibitory efficiency of the dual-targeted TPA PSs.
Topics & Concepts
RutheniumPhotodynamic therapyConjugateMitochondrionChemistryTwo-photon excitation microscopyAbsorption (acoustics)PhotochemistryCombinatorial chemistryBiophysicsBiochemistryFluorescenceMaterials scienceCatalysisBiologyOrganic chemistryPhysicsOpticsMathematicsMathematical analysisComposite materialNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesPorphyrin and Phthalocyanine Chemistry