Pangenome and genome variation analyses of pigs unveil genomic facets for their adaptation and agronomic characteristics
Dong Li, Yulong Wang, Tiantian Yuan, Minghao Cao, Yulin He, Lin Zhang, Xiang Li, Yifan Jiang, Ke Li, Jingchun Sun, Guangquan Lv, Guosheng Su, Qishan Wang, Yuchun Pan, Xinjian Li, Yu Jiang, Gongshe Yang, Martien A. M. Groenen, Martijn F. L. Derks, Rongrong Ding, Xiangdong Ding, Taiyong Yu
Abstract
The development of a comprehensive pig graph pangenome assembly encompassing 27 genomes represents the most extensive collection of pig genomic data to date. Analysis of this pangenome reveals the critical role of structural variations in driving adaptation and defining breed-specific traits. Notably, the study identifies BTF3 as a key candidate gene governing intramuscular fat deposition and meat quality in pigs. These findings underscore the power of pangenome approaches in uncovering novel genomic features underlying economically important agricultural traits. Collectively, these results demonstrate the value of leveraging large-scale, multi-genome analyses for advancing our understanding of livestock genomes and accelerating genetic improvement.