Explorations of CRISPR/Cas9 for improving the long-term efficacy of universal CAR-T cells in tumor immunotherapy
Muhammad Naeem, Abu Hazafa, Naheed Bano, Rashid Ali, Muhammad Farooq, Saiful Izwan Abd Razak, Tze Yan Lee, Sutha Devaraj
Topics & Concepts
CRISPRChimeric antigen receptorGenome editingCas9ImmunotherapyCancer immunotherapyCell therapyTumor microenvironmentComputational biologyBiologyCytokine release syndromeGenetic enhancementCancer researchT cellImmune systemImmunologyMedicineCellGeneGeneticsCAR-T cell therapy researchCRISPR and Genetic EngineeringNanowire Synthesis and Applications