Bi-directional differentiation of single bronchioalveolar stem cells during lung repair
Kuo Liu, Muxue Tang, Qiaozhen Liu, Ximeng Han, Hengwei Jin, Huan Zhu, Yan Li, Lingjuan He, Hongbin Ji, Bin Zhou
Abstract
The lung is a multi-functional organ that executes gas exchange and innate defense functions. The epithelium of respiratory tree consists of four regions from proximal to distal: trachea, bronchi, bronchiole, and alveolar regions. Multiple stem or progenitor cells are required for maintaining lung functions during normal condition and repair. The maintenance and repair of epithelium at different regions mainly depend on its resident stem or progenitor cells 1 , 2 , 3 .
Topics & Concepts
Stem cellLungChemistryCell biologyComputer scienceBiologyInternal medicineMedicineNeonatal Respiratory Health ResearchCongenital Diaphragmatic Hernia StudiesTissue Engineering and Regenerative Medicine