Purinergic signaling by TCRαβ+ double-negative T regulatory cells ameliorates liver ischemia–reperfusion injury
Hua Jin, Mingyang Li, Xiyu Wang, Lu Yang, Xinjie Zhong, Zihan Zhang, Xiaotong Han, Jingjing Zhu, Mengyi Li, Songlin Wang, Simon C. Robson, Guangyong Sun, Dong Zhang
Abstract
DNT validated the importance of adenosine/A2AR signaling, in promoting DNT survival and immunomodulatory function to protect against HIRI in vivo. In conclusion, purinergic signaling is crucial for DNT homeostasis in HIRI. Augmentation of CD39 or activation of A2AR signaling in DNT may provide novel therapeutic strategies to target innate immune disorders.
Topics & Concepts
Purinergic receptorReperfusion injuryPurinergic signallingT-cell receptorIschemiaPharmacologyMedicineCell biologyChemistryImmunologyAdenosineBiologyReceptorInternal medicineT cellAdenosine receptorImmune systemAgonistAdenosine and Purinergic SignalingNeurological Complications and SyndromesPancreatic function and diabetes