Pretreatment DWI with Histogram Analysis of the ADC in Predicting the Outcome of Advanced Oropharyngeal Cancer with Known Human Papillomavirus Status Treated with Chemoradiation
Marco Ravanelli, Alberto Grammatica, Marta Maddalo, Marco Ramanzin, Giorgio Maria Agazzi, Elena Tononcelli, Simonetta Battocchio, Paolo Bossi, Marika Vezzoli, Roberto Maroldi, Davide Farina
Abstract
BACKGROUND AND PURPOSE: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased in the period from the 1970s to 2004, due to increase of infection with human papilloma virus (HPV). This study aimed to examine the role of histogram analysis of the ADC in treatment response and survival prediction of patients with oropharyngeal squamous cell carcinoma and known human papillomavirus status. MATERIALS AND METHODS: values were corrected using the Benjamini-Hochberg method. RESULTS: = .01). CONCLUSIONS: ADC and human papillomavirus status are related to progression-free survival in patients treated with chemoradiation for advanced oropharyngeal squamous cell carcinoma; however, this association seems to result from the strong association between ADC and human papillomavirus status.