Therapeutic potentials and structure-activity relationship of 1,3-benzodioxole N-carbamothioyl carboxamide derivatives as selective and potent antagonists of P2X4 and P2X7 receptors
Abid Mahmood, Alexander Villinger, Jamshed Iqbal
Topics & Concepts
ChemistryCarboxamideAllosteric regulationDocking (animal)AntagonistIC50StereochemistryPharmacologyReceptorAntagonismBiochemistryIn vitroMedicineNursingAdenosine and Purinergic SignalingSynthesis and Biological EvaluationSulfur-Based Synthesis Techniques