A biocompatible β-cyclodextrin inclusion complex containing natural extracts: a promising antibiofilm agent
Obaydah Abd Alkader Alabrahim, Mostafa Fytory, Ahmed M. Abou‐Shanab, Jude Majed Lababidi, Wolfgang Fritzsche, Nagwa El‐Badri, Hassan Mohamed El-Said Azzazy
Abstract
. Furthermore, the BOS-βCD complex demonstrated a dual-action against bacterial biofilms where it prevented biofilm formation and disrupted established biofilms. This resulted in a significant reduction in biofilm biomass, with prevention and disruption rates reaching up to 93.78% and 82.17%, respectively. Additionally, the formula revealed an excellent biocompatibility profile with no induction of oxidative stress in human skin fibroblast cells. Our findings suggest that βCD nanoparticles loaded with BOS essential oils hold promise as an effective formula for preventing the formation of bacterial biofilms and combating preformed ones for use in relevant medical applications.