XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation
Laia Richart, Mary-Loup Picod-Chedotel, Michel Wassef, Manon Macario, Setareh Aflaki, Marion A. Salvador, Tiphaine Héry, Aurélien Dauphin, Julien Wicinski, Véronique Chevrier, Sonia Pastor, Geoffrey Guittard, Samuel Le Cam, Hanya A. Kamhawi, Rémy Castellano, Géraldine Guasch, Emmanuelle Charafe‐Jauffret, Édith Heard, Raphaël Margueron, Christophe Ginestier
Topics & Concepts
XISTBiologyX-inactivationMediatorStem cellCellular differentiationCell biologyEpigeneticsCancer researchDownregulation and upregulationGeneticsX chromosomeGeneGenomics and Chromatin DynamicsEpigenetics and DNA MethylationUbiquitin and proteasome pathways