N-of-1 trials: The epitome of personalized medicine?
Joyce P. Samuel, Susan H. Wootton, Jon E. Tyson
Abstract
Observational studies are notoriously susceptible to bias, and parallel-group randomized trials are important to identify the best overall treatment for eligible patients. Yet, such trials can be expected to be a misleading indicator of the best treatment for some subgroups or individual patients. In selected circumstances, patients can be treated in n-of-1 trials to address the inherent heterogeneity of treatment response in clinical populations. Such trials help to accomplish the ultimate goal of all biomedical research, to optimize the care of individual patients.
Topics & Concepts
Observational studyEpitomeClinical trialRandomized controlled trialMedicinePersonalized medicineIntensive care medicineAlternative medicineInternal medicineBioinformaticsComputer sciencePathologyBiologyMachine learningStatistical Methods in Clinical TrialsMeta-analysis and systematic reviewsAdvanced Causal Inference Techniques