Impaired folate binding of serine hydroxymethyltransferase 8 from soybean underlies resistance to the soybean cyst nematode
David A. Korasick, Pramod Kaitheri Kandoth, John J. Tanner, Melissa G. Mitchum, Lesa J. Beamer
Abstract
)-tetrahydrofolate-binding site. Ligand-binding and kinetic studies indicate severely reduced affinity for folate and dramatically impaired enzyme activity in Forrest SHMT8. These findings imply widespread effects on folate metabolism in soybean cv. Forrest that have implications for combating the widespread increase in virulent SCN.
Topics & Concepts
Soybean cyst nematodeSerine hydroxymethyltransferaseSerineGlycineBiologyBiochemistryGenotypeMethylenetetrahydrofolate reductaseEnzymePyridoxalGeneticsAmino acidGeneLegume Nitrogen Fixing SymbiosisNematode management and characterization studiesPhytase and its Applications