Electrochemical Chalcogenation of <i>β,γ</i>‐Unsaturated Amides and Oximes to Corresponding Oxazolines and Isoxazolines
Samrat Mallick, Mrinmay Baidya, Kingshuk Mahanty, Debabrata Maiti, Suman De Sarkar
Abstract
Abstract The current report represents a transition‐metal‐free synthesis of oxazoline and isoxazoline derivatives by a tandem electro‐oxidative chalcogenation‐cyclization process. Both C−Se and C−S bond‐forming protocols were developed without using any external oxidant and the reaction was performed at room temperature, open to the air. Using this methodology, 29 substituted oxazoline and 16 substituted isoxazoline derivatives were synthesized with up to 91% isolated yield. magnified image
Topics & Concepts
ChemistryOxazolineYield (engineering)TandemElectrochemistryCombinatorial chemistryTransition metalOrganic chemistryCatalysisElectrodeMetallurgyMaterials sciencePhysical chemistryComposite materialSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods