Energy depletion by cell proliferation sensitizes the kidney epithelial cells to injury
Pierre Galichon, Morgane Lannoy, Li Li, Justine Serre, Sophie Vandermeersch, David Legouis, M. Todd Valerius, Juliette Hadchouel, Joseph V. Bonventre
Abstract
ATP depletion is a hallmark of acute kidney injury. Proliferation is instrumental to kidney repair. We show that ATP levels vary during the cell cycle and that proliferation sensitizes renal epithelial cells to superimposed injuries in vitro. More proliferation and less energy production by the mitochondria are associated with adverse outcomes in injured kidney allografts. This suggests that controlling the timing of kidney repair might be beneficial to mitigate the extent of acute kidney injury.
Topics & Concepts
Cell growthCell biologyCell injuryEpitheliumChemistryAcute kidney injuryKidneyCellCancer researchApoptosisMedicineBiologyInternal medicinePathologyBiochemistryBirth, Development, and HealthPancreatic function and diabetesMitochondrial Function and Pathology