Highly Reproducible Hyperthermia Response in Water, Agar, and Cellular Environment by Discretely PEGylated Magnetite Nanoparticles
Idoia Castellanos-Rubio, Irati Rodrigo, Ane Olazagoitia‐Garmendia, Oihane K. Arriortua, Izaskun Gil de Muro, J. S. Garitaonandía, José Ramón Bilbao, M. L. Fdez-Gubieda, F. Plazaola, I. Orúe, Ainara Castellanos–Rubio, Maite Insausti
Abstract
magnetic hyperthermia was performed at 21 mT and 650 kHz during 1 h in a pre-endocytosis stage and complete cell death was achieved 48 h posthyperthermia. These optimal FM-NP@PEG formulations with high resistance to endocytosis and predictable magnetic response will aid the progress and accuracy of the emerging era of theranostics.
Topics & Concepts
Materials scienceNanoparticleMagnetiteMagnetic nanoparticlesPEG ratioMagnetic hyperthermiaNanotechnologyChemical engineeringViscosityEndocytosisBiophysicsChemistryCellBiochemistryEngineeringComposite materialFinanceBiologyMetallurgyEconomicsCharacterization and Applications of Magnetic NanoparticlesNanoparticle-Based Drug DeliveryMicrofluidic and Bio-sensing Technologies