Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of <i>C. elegans</i>
Giuseppe Calculli, Hyun Ju Lee, Koning Shen, Uyen Pham, Marija Herholz, Aleksandra Trifunović, Andrew Dillin, David Vı́lchez
Abstract
Besides altering the intracellular mitochondrial network of germline cells, PGL-1 aggregation also reduces the mitochondrial content of somatic tissues through long-range Wnt signaling pathway. This process induces the unfolded protein response of the mitochondria in the soma, promoting somatic mitochondrial fragmentation and aggregation of proteins linked with neurodegenerative diseases such as Huntington's and amyotrophic lateral sclerosis. Thus, the proteostasis status of germline stem cells coordinates mitochondrial networks and protein aggregation through the organism.
Topics & Concepts
ProteostasisCaenorhabditis elegansGermlineSomaBiologyMitochondrionProtein aggregationCell biologyModel organismGeneticsNeuroscienceGeneMitochondrial Function and PathologyGenetics, Aging, and Longevity in Model OrganismsBiochemical Acid Research Studies