Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells
Swati Haldar, Himanshu Agrawal, Sarama Saha, Alex R. Straughn, Partha Roy, Sham S. Kakar
Abstract
Follicle stimulating hormone (FSH) and its receptor (FSHR) have been reported to be responsible for several physiological functions and cancers. The responsiveness of stem cells and cancer stem cells towards the FSH-FSHR system make the function of FSH and its receptors more interesting in the context of cancer biology. This review is comprised of comprehensive information on FSH-FSHR signaling in normal physiology, gonadal stem cells, cancer cells, and potential options of utilizing FSH-FSHR system as an anti-cancer therapeutic target.
Topics & Concepts
Follicle-stimulating hormone receptorStem cellCancer stem cellFollicle-stimulating hormoneHormone receptorBiologyContext (archaeology)ReceptorCancerHormoneCancer researchCancer cellCell biologyInternal medicineEndocrinologyLuteinizing hormoneMedicineGeneticsBreast cancerPaleontologyReproductive Biology and FertilityOvarian function and disordersSperm and Testicular Function