A novel artificial intelligence protocol to investigate potential leads for Parkinson's disease
Zhidong Chen, Lu Zhao, Hsin‐Yi Chen, Jia-Ning Gong, Xu Chen, Calvin Yu‐Chian Chen
Abstract
). The results showed that 2007_22057 (an indole derivative), 2007_22325 (a valine anhydride) and 2007_15317 (an indole derivative) might be a potential medicine formula for the treatment of PD. Then there are three candidate compounds identified by the result of molecular dynamics.
Topics & Concepts
Indole testDocking (animal)Traditional Chinese medicineComputational biologyQuantitative structure–activity relationshipChemistryCombinatorial chemistryPharmacologyBioinformaticsMedicineStereochemistryBiologyPathologyAlternative medicineNursingComputational Drug Discovery MethodsRNA and protein synthesis mechanismsCytokine Signaling Pathways and Interactions