Biomechanical sensing of <i>in vivo</i> magnetic nanoparticle hyperthermia-treated melanoma using magnetomotive optical coherence elastography
Pin‐Chieh Huang, Eric J. Chaney, Edita Aksamitiene, Ronit Barkalifa, Darold R. Spillman, Bethany J Bogan, Stephen A. Boppart
Abstract
melanoma-bearing mice with MM-OCT and MM-OCE for the first time. It was discovered that the elasticity alteration of the melanoma tumor after MH treatment depends on both thermal dosage and the morphological features of the tumor. In summary, changes in tissue-level elasticity can potentially be a physically and physiologically meaningful metric and integrative therapeutic marker for MH treatment, while MM-OCE can be a suitable dosimetry technique.
Topics & Concepts
In vivoOptical coherence tomographyHyperthermiaElastographyBiomedical engineeringMelanomaHyperthermia TreatmentChemistryMagnetic nanoparticlesMaterials sciencePathologyBiophysicsNanoparticleCancer researchUltrasoundMedicineNanotechnologyRadiologyBiologyInternal medicineBiotechnologyPhotoacoustic and Ultrasonic ImagingUltrasound Imaging and ElastographyCharacterization and Applications of Magnetic Nanoparticles