Application of immune checkpoint inhibitors in immunotherapy for gastric cancer
Yi-Xiang Wu, Xiaoyu Zhou, Jian-Qi Wang, Gao-Min Chen, Jin-Xu Chen, Rong-Chang Wang, Jiongqiang Huang, Jingsong Chen
Abstract
Gastric cancer is the fifth most common cancer worldwide. With the development of immunotherapy, especially the application of immune checkpoint inhibitors (ICIs), the prognosis of advanced gastric cancer has improved. At present, ICIs combined with other therapies or dual ICI strategies in the treatment of advanced gastric cancer have shown clinical effectiveness and controllable safety. In addition, predictive biomarkers facilitate the precise selection of patients. Therefore, it is crucial to explore rational combinations and reliable predictive biomarkers for ICI therapy. This article reviews the recent advances in ICIs and relevant predictive biomarkers in the treatment of gastric cancer.