Discovery of novel tacrine derivatives as potent antiproliferative agents with CDKs inhibitory property
Wenwu Liu, Limeng Wu, Deping Li, Yaoguang Huang, Mingyue Liu, Wenjie Liu, Caizhi Tian, Xin Liu, Xiaowen Jiang, Xiaolong Hu, Xudong Gao, Zihua Xu, Hongyuan Lu, Qingchun Zhao
Topics & Concepts
TacrinePharmacologyChemistryAcetylcholinesteraseToxicityIn vivoCyclin-dependent kinaseIC50ButyrylcholinesteraseKinaseIn vitroApoptosisCell cycleAchéBiochemistryMedicineEnzymeBiologyOrganic chemistryBiotechnologyCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsCancer therapeutics and mechanisms